Telomere Distribution in Human Sperm Heads and Its Relation to Sperm Nuclear Morphology: A New Marker for Male Factor Infertility?
نویسندگان
چکیده
Infertility is a problem affecting an increasing number of couples worldwide. Currently, marker tests for male factor infertility are complex, highly technical and relatively subjective. Up to 40% cases currently diagnosed as idiopathic therefore, there clear need further research into better ways diagnosing it. Changes in sperm telomere length have been associated with closely linked DNA damage fragmentation, which also known be related infertility. However, distribution parameter thus far underexplored marker. Here, we assessed morphological parameters nuclei fertile control infertile cohorts. In addition, used 2D 3D fluorescence situ hybridization (FISH) compare between these two groups. Our findings indicate that the cohort were, on average, 2.9% larger area showed subtle differences head height width. Telomeres were mainly distributed towards periphery cohort, diminishing signals center nuclei. Sperm males, however, had more nuclei, finding supported by imaging. We conclude that, development, both morphology may prove useful investigative tools fertility clinic.
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: ['1661-6596', '1422-0067']
DOI: https://doi.org/10.3390/ijms22147599